After a bomb explosion devastates a residential apartment building, special agents Maggie Bell and Omar Adom "OA" Zidan of the New York office of the FBI investigate a possible war between rival gangs.

After eight people are poisoned at a New York deli, Bell and Zidan trace the crime to an unlikely culprit.

The team investigate the murders of 18 young women with assistance from a survivor associated with the deceased.

Bell and Zidan track down a sniper with a rising body count.

FBI Agents Maggie Bell and Omar Adom 'OA' Zidan investigate the murder of a Nuclear Power Plant Inspector.

After a senator's daughter is kidnapped and held for ransom, the FBI must find the little girl before their time limit expires; they must dig into the senator's past for clues who did this to his family.

Criminals masquerading as NYPD officers are robbing armored cars from the same armored car company.

Agent Bell and Zidan lead the search for an abducted former biological weapons chemist.

When a U.S. Marshal and a key witness are ambushed and murdered, Maggie and O.A. must find the person who leaked the information that led to their killings.

An illegal arms dealer who has turned informant gets assassinated; OA is the only agent that looks like him and assumes his identity, going undercover to stop the sale of more weapons.

When a judge and her daughter are murdered after she sentences a man to life in prison, Maggie and OA search for the killer; Dana has a history with the victim and a vested interest in the case.

When an alt-right provocateur is killed after giving a speech at a university in New York City, Maggie and OA investigate the school's more extreme political groups and rely on OA's sister, Amira, a student, for help.

Maggie and OA are on a mission to find a couple who are behind a spree of violent armed robberies that resulted in the death of an off-duty police officer.

After an investigative journalist is murdered, the team uncovers information linking the suspect to past cases. The victim's death also strikes a chord with Maggie, reminding her of the death of her reporter husband.

A serial bomber appears to be targeting Wall Street's elite. Maggie and OA search for a suspect who seems dead-set on revenge, while Dana deals with Spencer Briggs, a cocky profiler brought in to consult on the case.

When the daughter of a wealthy family is kidnapped in an attempt to gain notorious internet fame, Maggie and OA discover the kidnapper's plans go far beyond abduction in order to never be forgotten.

Maggie and Dana struggle to find justice for victims by a serial killer; the mayor limits the investigation to cut costs.

OA and Maggie team up with members of the FBI's Fugitives Department to track down a person wanted for murder who is then put on America's Top 10 Most Wanted list.

The team must take down a dangerous drug ring after an American diplomat is killed while being used as a pawn; Jubal and OA try to help friends from their past fight off their inner demons.

When a controversial senior leader from Egypt comes to New York for a heart transplant, OA struggles to balance his personal opinion with his professional duty when he is assigned to the security detail.

After a decorated FBI agent is murdered, the team investigates and uncovers the man led a double life. Also, Maggie struggles with what information she should reveal to the agent's widow, who is also her personal friend.

A woman with information about the death of Maggie's husband is abducted, leading the team to uncover a massive criminal operation.